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01【專題演講】5/19(五) 陽明大學神經科學研究所林慶波教授2017.05.12
物理系邀請陽明大學神經科學研究所林慶波教授蒞臨本校演講,
內容是有關大腦結構與功能性連結的技術與應用,
歡迎有興趣的師生前往聆聽討論。

講題:Mapping the human brain connectome

講者:陽明大學神經科學研究所林慶波教授


時間:5/19(五)15:00-17:00


地點:成功大學物理二館地下室 (49X04)

個人CV: http://bclab.ym.edu.tw/orange.html 
     
演講摘要
Knowledge of functional roles of brain areas and associated connections are of critical importance in the understanding of normal brain functions as well as brain disorders. The connectivity pattern is formed by structural links of synapses and associated fiber pathways and the underlying causal relationships measured as cross-correlations or coherence. By extension neural codes, neural activity is thus constrained by the connectivity. 
For decades, neuroscientists exhibited little interest in the connections due to the limit of non-invasive technique. By means of water molecular anisotropic diffusion and blood oxygen level measurement, brain structural and functional connections could be calculated through modern diffusion and functional MRI. These imaging technologies open a great window to understand functional anatomy on the basis of its structural substrates. Meanwhile, the complexity of higher brain systems emerged another challenge to explain the rich functionality that arises from a relatively fixed structure. To simplify the problem, the topology of brain networks has been analyzed and proven successful in sociology and systems biology. Recent studies have shown its close coupling with the cognitive functions, not only personal variation in cognitive performance such as memory, attention and language ability, but also behavioral deviation or dysfunction. 
Within the lecture, modern imaging technologies for mapping human brain connectome and the connectomics of brain disorders, including dementia and schizophrenia will be discussed. Meanwhile, technical limitation of these non-invasive tools will be highlighted.

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